Bayesian hidden Markov model analysis of single-molecule force spectroscopy: Characterizing kinetics under measurement uncertainty

John D. Chodera,1, ∗ Phillip Elms,1, 2, 3 Frank Noé,4 Bettina Keller,4 Christian M. Kaiser,1, 5 Aaron Ewall-Wice,6 Susan Marqusee,1, 7, 3 Carlos Bustamante,1, 7, 3, 5, 8, 9 and Nina Singhal Hinrichs10 California Institute of Quantitative Biosciences (QB3), University of California, Berkeley, CA 94720, USA Biophysics Graduate Group, University of California, Berkeley, CA 94720, USA Jason L. Choy Laboratory of Single Molecule Biophysics, Institute for Quantitative Biosciences, University of California, Berkeley, CA 94720, USA DFG Research Center Matheon, FU Berlin, Arnimallee 6, 14195 Berlin, Germany Department of Physics, University of California, Berkeley, CA 94720, USA University of Chicago, IL 60637, USA Department of Molecular & Cell Biology, University of California, Berkeley, CA 94720, USA Department of Chemistry, University of California, Berkeley, CA 94720, USA Howard Hughes Medical Institute, University of California, Berkeley, CA 94720, USA Departments of Statistics and Computer Science, University of Chicago, IL 60637, USA (Dated: August 5, 2011)